Immunology and Microbiology
8 years ago

New Discovery Unlocks Potential to Enhance Immune Response and Suppress Antibodies.

Elsevier eBooks
TWO LOCI SELECTIVELY EXPRESSED ON FUNCTIONALLY DIFFERENT T CELLS**This work was supported by grants from the Ministry of Education, Science and Culture and the Ministry of Health, Japan
Ko Okumura, Takeshi Tokuhisa, Toshitada Takemori, Tomio Tada

Paper Summary

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Two different types of T cells have been found to express specific genes that either enhance or suppress the immune response, while B cells do not have these genes. The genes are located in the I-A and I-J subregions. An experiment showed that an antiserum could absorb these T cell factors even after removing B cells, indicating their specificity to T cells. This suggests that there are at least two loci in the I-A and I-J subregions that code for molecules on T cells but not on B cells.