Medicine
8 years ago

New method simplifies sample size determination for logistic regression analysis.

American Journal of Epidemiology
Sample Size and Power Determination for a Binary Outcome and an Ordinal Exposure when Logistic Regression Analysis Is Planned
Shelley B. Bull

Paper Summary

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The article discusses how to determine the sample size needed for a study looking at the relationship between a gene called mdr1 and how tumors respond to chemotherapy. The researchers developed simple methods to calculate this based on the levels of mdr1 expression. They focused on detecting a pattern where higher mdr1 levels are linked to better tumor response. The study aimed to make it easier for researchers to plan similar investigations in the future.