New method for odds ratio analysis improves accuracy in large datasets!
The modified profile likelihood method is used to estimate odds ratios in regression analysis of 2 x 2 tables. Traditional methods can be biased or impractical in large problems, but this new approach provides accurate estimates. As the number of tables increases, the modified profile likelihood estimator remains consistent while the traditional estimator becomes unreliable. The new method shows minimal bias for odds ratios below 5.