Medicine
8 years ago

Obesity-linked kidney disease could be driven by growth factor imbalance

Nutrition Research
mRNA expression for insulin-like growth factor 1, receptors of growth hormone and IGF-1 and transforming growth factor-β in the kidney and liver of Zucker rats
Winnie Chan, Marian Wang, Roy J. Martin, Howard Trachtman, Satoshi Hisano, James C.M. Chan

Paper Summary

Obese Zucker rats have enlarged kidneys due to early mesangial proliferation. The mRNA levels of IGF-I and GHR in the kidney and liver of obese rats are lower than in lean rats. However, the mRNA levels of IGF-1R in the kidney of obese rats are higher, suggesting increased IGF-1 binding leading to kidney hypertrophy.

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