Metal ions like Zn, Cu, and Mn affect the behavior of a cancer-fighting antibiotic called streptonigrin by changing its electrochemistry. These ions can shift the reduction of certain components of the antibiotic to higher potentials, forming complexes that alter its redox chemistry. The presence of these metal ions helps in the initial reduction of streptonigrin by capturing the partially reduced form of the antibiotic. This study shows how metal ions influence the electrochemical properties of streptonigrin, potentially impacting its effectiveness in fighting cancer.