Biochemistry, Genetics and Molecular Biology
8 years ago

Drift-driven decline: Mutations shift to benefit as populations adapt.

PLoS Biology
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects
Olin Silander, Olivier Tenaillon, Lin Chao

Paper Summary

Populations adapting to a constant environment reach a fitness plateau. In small populations, fitness can decrease due to drift. Changes in beneficial mutation rate, not mutation size, drive fitness changes.

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