The GISS climate model includes interactive chemistry for ozone and methane in historical and future simulations. The model shows good agreement with observations for ozone and methane levels, but still has some areas for improvement. The model predicts changes in ozone forcing and surface temperatures over the 20th and 21st centuries, with different outcomes depending on emission scenarios. Stratospheric ozone depletion affects surface winds and ocean circulation, leading to shifts in tropical precipitation patterns. Overall, the model provides valuable insights into the interactions between ozone, methane, and climate change.