Medicine
8 years ago

Premature hyperactivation in sperm linked to impaired fertilization potential.

Developmental Biology
Sperm from tw32/+ mice: Capacitation is normal, but hyperactivation is premature and nonhyperactivated sperm are slow
Patricia Olds‐Clarke

Paper Summary

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The study looked at sperm from mice with a specific genetic trait that affects fertilization. They found that the sperm from these mice showed normal capacitation (preparation for fertilization) but had premature hyperactivation (increased swimming speed). The sperm that did not hyperactivate were slower compared to normal sperm. This suggests that the dysfunctional sperm with the genetic trait may be the slower ones.