Neuroscience
8 years ago

Ghrelin Hormone Boosts Appetite, Paving Way for Obesity Treatment

Endocrinology
Central Effect of Ghrelin, an Endogenous Growth Hormone Secretagogue, on Hypothalamic Peptide Gene Expression
Jun Kamegai, Hideki Tamura, Takako Shimizu, Shinya Ishii, Hitoshi Sugihara, Ichiji Wakabayashi

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Ghrelin, a hormone that stimulates growth, was studied to see how it affects the brain. Researchers found that when ghrelin was given to rats in the brain, it increased the levels of a gene called AGRP in the hypothalamus. This led to the rats eating more food. However, ghrelin did not affect the release of growth hormone from the pituitary gland. This shows that ghrelin can make rats eat more by changing gene levels in the brain, rather than by releasing growth hormone.