Mathematics
8 years ago

New method for comparing treatments in trials could improve vaccine studies.

Statistics in Medicine
Test statistics and sample size formulae for comparative binomial trials with null hypothesis of non‐zero risk difference or non‐unity relative risk
Paddy Farrington, Godfrey Manning

Paper Summary

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The article discusses how to compare two treatments in medical studies when we want to show a significant difference or equivalence between them. Traditional methods don't work in these cases. The researchers suggest using certain statistical methods and formulas to determine the sample size needed for these types of trials. They applied these methods to studies on pertussis vaccine.