The researchers investigated how a hormone called ghrelin may influence overeating in diabetes. They studied rats with uncontrolled diabetes and found that diabetic rats ate a lot more and had higher ghrelin levels in their blood compared to healthy rats. Insulin treatment helped reverse these changes. Additionally, diabetic rats had lower levels of a hormone called leptin and increased levels of a brain messenger called NPY, which can increase appetite. Blocking the ghrelin receptor partially reversed the excessive eating in diabetic rats. This study suggests that high ghrelin and low leptin levels in diabetes, along with increased NPY in the brain, may drive overeating.