Medicine
8 years ago

Genetic variations in key pathway genes linked to non-Hodgkin lymphoma risk.

Leukemia Research
Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma
Yingtai Chen, Qing Lan, Tongzhang Zheng, Nan Zhao, Theodore R. Holford, Catherine C. Lerro, Min Dai, Huang Huang, Jiaxin Liang, Shuangge Ma, Brian P. Leaderer, Peter Boyle, Stephen J. Chanock, Nathaniel Rothman, Yawei Zhang

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Genetic variations in certain JAK/STAT pathway genes may increase the risk of non-Hodgkin lymphoma. Researchers studied 12 genes in this pathway and found that specific variations in STAT3 and STAT4 were linked to a higher risk of NHL. This suggests that these genetic differences could be involved in the development of lymphoma and should be looked into further.