New method detects genetic interactions impacting traits, revolutionizing personalized medicine.
The researchers studied how differences in the variance of traits among genetic groups can help identify potential interactions between genes and other factors. They tested different statistical methods to see which one worked best for this purpose. They found that Bartlett's test and Levene's test were effective in detecting these interactions, but the power of the test can vary depending on the unknown factors involved. They also applied their method to a real-world study on C-reactive protein levels in a large population and confirmed previous findings. Overall, screening for differences in variances among genetic groups can be a useful way to identify genes that may be involved in complex interactions.