Organ cryopreservation using freezing can damage organs due to ice formation. Vitrification, a new method without ice, is more successful for small tissues but needs improvement for larger organs. Insects like Cujucus clavipes beetle larvae survive extreme cold by using cryoprotectants and antifreeze compounds. These compounds can increase cell viability during cryopreservation. Antifreeze glycolipids from insects, frogs, and plants show promise in improving organ cryopreservation. Understanding how animals prepare for cold can help replicate these processes in organ donors and during organ preservation.