Medicine
8 years ago

Cryopreservation damages bovine sperm DNA by inducing hydrogen peroxide synthesis, despite preserving other viability markers.

Theriogenology
Effects of cryopreservation on sperm viability, synthesis of reactive oxygen species, and DNA damage of bovine sperm
Hakan Gürler, Eleni Malama, M. Heppelmann, Oğuz Çalışıcı, C. Leiding, John P. Kastelic, H. Bollwein

Paper Summary

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The study looked at how freezing affects the quality of bull sperm. They compared fresh sperm to frozen and thawed sperm over 24 hours. While most sperm quality changed during incubation, DNA damage stayed the same in fresh sperm but increased in frozen sperm. The researchers found that the increase in DNA damage in frozen sperm was related to the production of a specific reactive oxygen species called H2O2. This suggests that freezing sperm can lead to DNA damage through the production of H2O2.