Applying bio-fertilizer and chemical fertilizer to wheat crops can increase grain and straw yield, as well as the uptake of nutrients like nitrogen and phosphorus. When both types of fertilizers are used together, they have a synergistic effect, leading to even higher yields. Inoculating with specific bacteria like Azospirillum brasilense and Bacillus polymyxa can save on nitrogen and phosphorus fertilizers while still boosting crop growth. Overall, combining bio-fertilizers and chemical fertilizers can significantly improve wheat production by providing more nutrients to the plants, resulting in increased yields.