The article discusses the use of natural preservatives in food to replace chemical preservatives. These natural preservatives, derived from plants, animals, and microbes, help prevent food spoilage by inhibiting microbial growth and oxidation. They also maintain the nutritional value of food while ensuring its safety. The research focuses on the mechanisms of action of these natural preservatives and their application in food preservation. The findings suggest that natural biological preservatives can be effective in preserving food and improving its safety without the use of chemical additives.