Reduction application of organic-inorganic compound fertilizer decreased tobacco plant height, stem thickness, leaf size, yield, and quality compared to conventional inorganic fertilizer. The lower nitrogen in the organic-inorganic compound fertilizer hindered tobacco growth and tillering, leading to lower yield and quality. However, reducing the organic-inorganic compound fertilizer slightly increased stem thickness, leaf size, and output value of tobacco. This fertilizer has potential for saving fertilizer while maintaining tobacco quality.