The study looked at how different diets with high amounts of sorbitol and saccharose affected enzymes and liver mass in rats during different seasons. Rats fed with sorbitol were thinner and had diarrhea compared to those fed with saccharose. Liver mass was lower in autumn and winter than in spring and summer. Enzyme activity varied between seasons and diets, with some enzymes being higher or lower depending on the diet and time of year. The results show that the body's molecular mechanisms adapt to changes in the environment, including genetic factors, which affect enzyme activity.