Muscle protein turnover in uremia is affected by changes in protein synthesis and degradation. In uremia, measuring protein turnover in the body can be tricky due to errors in amino acid transport and catabolism. Traditional methods for measuring protein degradation may not accurately reflect what's happening in muscle tissue. Using radiolabeled amino acids in lab studies can provide more reliable estimates of muscle protein turnover. Factors like insulin-resistance and fasting can impact protein turnover in uremic muscle. Overall, understanding how protein turnover is altered in uremia is important for managing muscle health in patients with kidney disease.