The researchers studied how two drugs, diphenylhydantoin (DPH) and diazoxide, affect insulin release in the pancreas. They found that DPH completely stops the second phase of insulin release, while diazoxide initially inhibits release but then allows for a rebound effect. DPH hinders the early response to glucose, while diazoxide divides the insulin release process into two steps. The computer analysis suggests that DPH blocks insulin release from a specific compartment, while diazoxide causes insulin to accumulate in an earlier part of the compartment.