Loss of Hipk Impairs JAK/STAT Signaling, Leading to Blood Cell Tumors.
A new study found that a protein called Hipk is crucial for a signaling pathway called JAK/STAT, which is important for cell activity. When Hipk is missing, JAK/STAT doesn't work properly in different tissues. On the other hand, too much Hipk can cause blood cell tumors in fruit flies. The researchers showed that Hipk interacts with a key player in the pathway, called Stat92E. This discovery suggests that Hipk is essential for JAK/STAT signaling to function correctly.