Sesame seeds and oil have important health benefits. Roasting sesame seeds at high temperatures creates a unique flavor and color in the oil. Some compounds in sesame seeds are stable during roasting, while others change. Deep-roasted sesame oil has strong antioxidant properties due to specific compounds. A new antioxidant compound, sesaminol, is formed during the purification process of unroasted sesame oil. Deep-roasted sesame flavor concentrates have anti-blood clotting effects. Extracting specific compounds from sesame seeds or oil using supercritical CO2 extraction can isolate beneficial components like antioxidants and flavor compounds.