The researchers studied how a drug called nicorandil affects the blood sugar-lowering effects of glibenclamide in diabetic rats. They found that when nicorandil was given along with glibenclamide, it actually increased blood sugar levels instead of lowering them. This suggests that nicorandil interferes with the way glibenclamide works in the body, making diabetes worse. It's important to be cautious when combining these two types of drugs in diabetic patients.