The article discusses how customer relationship management (CRM) is crucial for businesses in the era of E-Commerce. It explains that CRM is a vital source of information for business activities and plays a key role in satisfying customer needs. The study highlights the importance of integrating CRM with E-Commerce and provides specific strategies for managing customer relationships effectively in this digital environment. The research concludes that CRM is not just a new management concept but also a critical component of E-Commerce success. By implementing the proposed measures, enterprises can enhance their customer relationships and achieve better results in their business operations.