Chronic early-life stress can affect ghrelin and insulin levels differently in male and female mice. This stress exposure can lead to changes in the brain's feeding and metabolic circuits, potentially impacting energy balance and feeding behavior in adulthood. The study showed that ghrelin levels were more affected in females, while insulin levels increased in both sexes after stress exposure. The density of certain brain fibers related to feeding behavior was altered in both male and female mice exposed to stress. These changes in the brain's regulatory circuits could contribute to a higher risk of developing metabolic disorders later in life.