Buffer preparation in bioprocessing can be challenging, but a new method called In-Line Conditioning (IC) simplifies the process. IC involves formulating buffers in-line from concentrated stock solutions and diluting them with water. This method helps ensure consistent buffer delivery, reproducibility, and cost-effectiveness. By automatically controlling critical parameters like conductivity and pH, IC reduces buffer preparation time and the need for large buffer tanks. Overall, IC technology offers a more efficient and automated way to handle buffers in bioprocessing.