The article explores how innovation is changing in today's world and focuses on open innovation systems and their international integration. It identifies key elements like innovation entrepreneurship, networks, cooperation, clusters, and ecosystems. The main driver of innovation is entrepreneurial activity that spans technology, management, and society. Collaboration in innovation involves sharing technology, information, and joint projects. Innovation ecosystems and clusters are crucial for open innovation. International cooperation among clusters is a growing trend. Innovation development boosts human capital and innovation levels. Internationalization of human capital happens through global scientific cooperation. The main goal is to understand and promote open innovation systems for innovation development.