Land-use and land-cover changes in Thakhek District of Laos were studied from 1987 to 2016 using remote sensing and GIS techniques. The main land-cover types were dense forest, agriculture, built-up areas, open forest, and waterbodies. Over this period, there was a 27% change in the study area, with an increase in agriculture and built-up land, dense forests, and waterbodies, and a decrease in open forests. Most land conversions were reversible. This study shows how remote sensing and GIS can be used to monitor changes in land use over time in tropical environments, providing valuable information for conservation and land management strategies.