Medicine
6 years ago

New method to screen Alzheimer's inhibitors offers hope for treatment breakthrough.

Journal of Visualized Experiments
A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
Chunhui Huang, Xu Dilin, Ke Zhang, Jieyi Shentu, Sicheng Yan, Wu Dapeng, Qinwen Wang, Cui Wei

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The researchers developed a method to prepare and analyze toxic Aβ1-42 oligomers, which are linked to Alzheimer's disease. They used a specific antibody to detect these harmful oligomers in samples, allowing for the screening of potential inhibitors. This approach can help identify compounds that may prevent neurodegeneration in Alzheimer's disease.