Climate change and human activities impact streamflow in the Wanquan River Basin in southern China. The study analyzed 54 years of data and found that while annual streamflow decreased slightly, temperatures increased. Precipitation decreased in the upstream region but increased downstream. An abrupt change in streamflow occurred in 1974. Climate change increased streamflow from the 1970s to the 2000s, while human activities decreased it. Overall, climate change had a greater impact on streamflow than human activities in the basin.