The wastewater resistome is a collection of antibiotic resistant genes found in bacteria living in wastewater. These genes can resist many types of antibiotics, posing a risk for spreading antibiotic resistance to humans and animals. Factors like low doses of antibiotics and environmental stress can contribute to the enrichment of resistance genes in wastewater. The exact ways these genes survive and spread in wastewater are still not fully understood. To address this issue, better wastewater treatment methods are needed to reduce the presence of antibiotic resistant bacteria and genes.