Medicine
6 years ago

Sperm DNA Damage Reduced by Lowering Concentration for Assisted Reproduction

Journal of Assisted Reproduction and Genetics
Dynamic assessment of human sperm DNA damage II: the effect of sperm concentration adjustment during processing
Eva Tvrdá, Francisca Arroyo, Michal Ďuračka, Carmen López‐Fernández, Jaime Gosálvez

Paper Summary

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The researchers studied how adjusting the concentration of sperm in samples affects sperm DNA quality and longevity. They used semen samples from 30 donors and adjusted the sperm concentration to different levels. After incubating the samples, they found that lower sperm concentrations resulted in slower DNA fragmentation. Samples with higher concentrations had higher DNA damage after 2 hours of incubation. To preserve sperm DNA integrity for assisted reproductive techniques, it is recommended to use sperm concentrations below 25 million per milliliter.