Medicine
6 years ago

STAT proteins in cancer and inflammation: New hope for targeted therapies!

Frontiers in Oncology
Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication
Chin-Yap Loh, Aditya Arya, Ahmed Fadhil Naema, Won Fen Wong, Gautam Sethi, Chung Yeng Looi

Paper Summary

The STAT pathway, connected to JAK proteins, helps cells respond to signals. STAT3 and STAT5 promote cancer, while STAT1 suppresses it. Persistent STAT3/5 activation can lead to chronic inflammation and increase cancer risk. Researchers are exploring using nanoparticle delivery systems to target STAT3/5 with siRNA for cancer therapy.

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