Medicine
5 years ago

Unlocking Cancer Treatment Potential: Targeting STAT Proteins Holds Key

Seminars in Cancer Biology
The potential and controversy of targeting STAT family members in cancer
Yannick Verhoeven, Sam Tilborghs, Julie Jacobs, Jorrit De Waele, Delphine Quatannens, Christophe Deben, Hans Prenen, Patrick Pauwels, Xuan Bich Trinh, An Wouters, Evelien Smits, Filip Lardon, Peter A. van Dam

Paper Summary

Related papers

Theme background image
Medicine
3 years ago

STAT Proteins Fuel Prostate Cancer Spread and Treatment Resistance.

p53 Cancer
STAT3 Cancer
Pim Oncogenes
Theme background image
Medicine
3 years ago

Unlocking the key to growth, survival, and defense with STAT3 gene.

STAT3 Cancer
Theme background image
Medicine
8 years ago

C-Cbl protein discovery unlocks new control over immune response proteins.

STAT3 Cancer
RNA Processing
MicroRNA Regulation
1 view

The STAT family of proteins plays a crucial role in regulating cell processes and has been linked to cancer development and treatment resistance. Specifically, STAT3 and STAT5 are important in cancer biology, acting as both oncogenes and tumor suppressors. Mutations in STAT signaling and abnormal activation of STAT pathways could help predict how well a patient responds to immunotherapy and targeted treatments. This review explores the potential of targeting STAT proteins in cancer treatment, highlighting their dual role in promoting and inhibiting tumor growth.