Biochemistry, Genetics and Molecular Biology
5 years ago

Bovine embryos can regenerate lost tissues, paving way for new reproductive technologies

Journal of Biological Chemistry
Trophectoderm regeneration to support full-term development in the inner cell mass isolated from bovine blastocyst
Nanami Kohri, Hiroki Akizawa, Sakie Iisaka, Hanako Bai, Yuchio Yanagawa, Masashi Takahashi, Masaya Komatsu, Masahito Kawai, Masashi Nagano, Manabu Kawahara

Paper Summary

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The researchers investigated whether isolated mouse and bovine inner cell masses (ICMs) could regenerate trophectoderm (TE) cells. They found that a calf was successfully generated from the bovine ICM, but no mouse ICMs developed to term. The differences in developmental competency were linked to the expression of the SOX17 protein, which plays a role in cell fate decisions. The study suggests that bovine ICMs maintain TE regeneration ability longer than mouse ICMs, and that structural factors influence cell differentiation in mammalian embryos.