Biochemistry, Genetics and Molecular Biology
5 years ago

New study reveals key protein's role in cancer development and treatment.

PLoS ONE
Hipk is required for JAK/STAT activity during development and tumorigenesis
Gritta Tettweiler, Jessica A. Blaquiere, Nathan B. Wray, Esther M. Verheyen

Paper Summary

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The study found that a protein called Hipk is important for a signaling pathway called JAK/STAT in fruit flies. When Hipk is overexpressed, it can cause tumors, similar to when JAK/STAT is too active. Removing Hipk can reduce the effects of overactive JAK/STAT. Hipk interacts with another protein, Stat92E, and helps control where it goes in the cell. This shows that Hipk is needed for JAK/STAT to work properly.