Alternatives to high-global-warming refrigerants (HFCs) have been developed and are being used in various sectors. Countries like Australia, Canada, EU, Japan, and the US are introducing regulations to promote the use of low-global-warming-potential replacements for HFCs. These alternatives include next-gen fluorocarbons, hydrocarbons, and non-fluorocarbon refrigerants. These alternatives have the potential to decrease energy use significantly in cooling systems. By providing more options and reducing emissions, these alternatives also create competition and help lower prices compared to patented HFO substitutes. Overall, non-fluorinated options could potentially replace about 50% of high-GWP HFCs, and have proven effective in reducing reliance on harmful ozone-depleting substances in the past.