Immunology and Microbiology
4 years ago

New drug improves memory in elderly rats by reducing inflammation

Zhonghua mazuixue zazhi
Effects of exendin-4 on GFAP and IL-1βexpression in hippocampi of aged rats
Liang Zhang, 闵苏, 黎平, 律峰, 郝学超, 谢飞, 陈其彬, Liu Li, 沈一维, 朱贤琳, 魏珂, 陈婧

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Exendin-4 helps improve memory in older rats by reducing inflammation in their brains and keeping their blood sugar stable after surgery. The researchers studied how exendin-4 affected the levels of certain proteins in the hippocampus of aged rats. They found that rats given exendin-4 had better memory and lower levels of inflammation compared to rats not given the drug. This suggests that exendin-4 could be a potential treatment for cognitive issues in older individuals.