Medicine
4 years ago

Spinal Cord Discovery Unlocks Potential for Treating Persistent Postoperative Pain

Zhonghua mazuixue zazhi
Relationship between p38MAPK and GRK2 in spinal cord in development of persistent postoperative pain in rats
Xingguo Hu, Le Qi, Gongjian Liu, Zeng Yin-ming

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The study looked at how two proteins, p38MAPK and GRK2, are related to persistent postoperative pain in rats. They used different groups of rats and measured their pain levels and protein levels in the spinal cord. The results showed that when GRK2 levels were low, p38MAPK was more active, leading to more pain in the rats. This suggests that the levels of these proteins in the spinal cord play a role in the development of persistent postoperative pain.