Medicine
4 years ago

New Treatment Offers Hope for Infants with Debilitating Seizures

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Zhonghua shiyong erke linchuang zazhi
Comparison of efficacy of adrenocorticotrophic hormone and methylprednisolone on rat models of infantile spasm
Tan Jia, Li L. Shen, Xiaoli Zhang, Kaixian Du, Xiaoli Li, Li Xiao, Ling Gan, Qiliang Guo

Paper Summary

The study compared the effectiveness of two treatments, ACTH and methylprednisolone, on infantile spasms in rat models. Rats were induced with seizures and then treated with either ACTH, methylprednisolone, or saline. The results showed that ACTH and methylprednisolone reduced seizure severity and increased latency period compared to saline. Both treatments also decreased the expression of a hormone related to seizures in the brain. Overall, ACTH and methylprednisolone were found to be more effective in reducing seizures in the rat models compared to saline.

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