Pesticides are chemicals used in farming to protect crops from pests, but their indiscriminate use can harm human health. Over 900 pesticides are registered, with about 200,000 people dying annually from pesticide exposure, mostly in low-income countries. The chapter discusses the history of pesticide use, types of chemicals, poisoning symptoms, and banned pesticides. It also provides guidance on safe handling, storage, and disposal of pesticides, as well as the use of biopesticides and integrated pest management to reduce environmental and health risks. Awareness and safety measures are crucial for protecting farmers and farmworkers from the harmful effects of pesticides.