Infertile men with cystic fibrosis mutations face severe reproductive challenges
The study looked at 71 infertile men with two CFTR mutations to understand their andrological findings. They found that most of these men had azoospermia (no sperm in semen) and some had low testosterone levels. The size of their testes was slightly larger than normal, and some had abnormalities in semen parameters like volume and pH. Only a small percentage had a specific condition called congenital bilateral absence of the vas deferens (CBAVD). The researchers recommend CFTR mutation analysis for men with unexplained azoospermia and normal gonadotropin levels.
