Medicine
4 years ago

Deficiency in LCN8 leads to sperm quality issues in mice.

Biochemical and Biophysical Research Communications
Deficiency for Lcn8 causes epididymal sperm maturation defects in mice
Zongzhuang Wen, Dongyue Liu, Haixia Zhu, Xiaoyang Sun, Xiao Yu, Zhuchun Lin, Aizhen Zhang, Chao Ye, Jiangang Gao

Paper Summary

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The study found that mice lacking the LCN8 protein had sperm maturation issues in the epididymis, leading to abnormal sperm shape, reduced sperm movement, and increased sperm acrosome reaction. Knocking out LCN9 did not affect sperm quality. This shows that LCN8 plays a crucial role in maintaining sperm quality during maturation in the epididymis.