Neuroscience
4 years ago

Leptin discovery could revolutionize weight loss strategies for fasting individuals

Journal of the Endocrine Society
Leptin Regulates Hypothalamus-Pituitary-Thyroid Axis via TRH in Energy Expenditure During Fasting: The Study on TRH Deficient Mouse
Yuri Kondo, Atsushi Ozawa, Takuya Watanabe, Masayuki Yoshioka, Sayaka Yamada, Ayaka Nishikido, Emi Ishida, Kazuhiko Horiguchi, Shunichi Matsumoto, Yasuyo Nakajima, Shuichi Okada, Masanobu Yamada

Paper Summary

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Leptin helps regulate energy expenditure during fasting by affecting the thyroid gland through TRH. TRH is a hormone that plays a role in the body's metabolism. In a study with mice lacking TRH, fasting still decreased thyroid hormone levels, but leptin couldn't restore them. This suggests that TRH is necessary for leptin to regulate thyroid hormones during fasting.