Medicine
3 years ago

New risk score model predicts glioma prognosis with high accuracy.

Frontiers in Genetics
Bioinformatics Analysis of Expression Profiles and Prognostic Values of the Signal Transducer and Activator of Transcription Family Genes in Glioma
Wei Ji, Yuankun Liu, Bin Xu, Jie Mei, Chao Cheng, Yong Xiao, Kun Yang, Weiyi Huang, Jiantong Jiao, Hongyi Liu, J.F. Shao

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Signal transducer and activator of transcription (STAT) genes play a role in cancer progression, including glioma. In this study, the expression and prognostic value of STAT genes in glioma were investigated. High levels of STAT1/2/3/5A/6 were linked to poorer survival, while low STAT5B levels were associated with better outcomes. A combined analysis of these genes showed a stronger predictive value than individual genes. A risk score model was developed to predict glioma prognosis accurately. STAT genes were also found to be involved in immune response and specific signaling pathways in glioma. Overall, this study provides insights into the role of STAT genes in glioma and offers a new tool for predicting patient outcomes.