The study assessed metal contamination in sediments of the Mohammad Abad River in Northern Iran. Samples from six sites were analyzed for eleven heavy metals. Most metals showed low to moderate pollution levels, except for selenium and arsenic which had very high pollution levels. The contamination was mainly from natural sources for chromium, manganese, iron, cobalt, nickel, zinc, and aluminum, while selenium and arsenic were from human activities. Continuous monitoring of selenium and arsenic in the river is recommended to protect public health and the environment.