The researchers studied how chemical-induced diabetes affects the brain-hormone connection with the thyroid gland in male rats. They used a chemical called streptozotocin to induce diabetes. After 2 weeks, diabetic rats had lower body weight, higher blood sugar, and lower levels of thyroid hormones in their blood compared to non-diabetic rats. The diabetic rats had a reduced release of a hormone called TRH in the brain, which is important for thyroid function. This lower release of TRH might explain why the diabetic rats had lower levels of thyroid hormones in their blood. The study suggests that diabetes can affect the brain's ability to control the thyroid gland, leading to changes in hormone levels in the body.