The article discusses how the SARS-CoV-2 virus spread globally, leading to changes in diagnosis methods and treatments. New diagnostic methods like whole genome sequencing and rapid antigen tests are being used. Researchers are studying mutations in the virus and developing new approaches to detect them. Labs are now using sample pooling and reflex testing with WGS. The accuracy and usefulness of these methods are being assessed using rapid sequencing techniques. Changes in PCR primer binding sites are being monitored, and quality assurance programs are being updated. Studies in Australia have helped track the spread of COVID-19 using genomic data.