Sperm DNA damage may undermine fertility despite normal semen tests
The researchers studied male infertility by analyzing semen samples from 118 patients at a fertility clinic. They checked both traditional sperm measures and DNA fragmentation levels. Patients with high DNA fragmentation had lower sperm quality. Surprisingly, some men with normal sperm had high DNA damage. Older patients tended to have more DNA fragmentation. In the low DNA fragmentation group, chances of conception and live births were higher. The study suggests that adding DNA fragmentation tests to routine semen analysis can provide better insights into male fertility.